Environment and pharmaceuticals / Environmentally classified pharmaceuticals / R Respiratory system

Environmentally classified pharmaceuticals

Two substances may have the same risk values but different PBT values, but the risk assessment can also be different even if the PBT values are the same. When assessing a medication's environmental impact, consideration should be given to both environmental risk and environmental hazard since bioaccumulation and persistence are not included in the risk assessment.

The Swedish Association of the Pharmaceutical Industry conducted the environmental risk assessment, beginning in 2005.

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Last updated: 2011-07-20

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R Respiratory system

Substance	Risk	PBT	P	B	T	Volume in DDD
R01 Nasal preparations
ipratropium	cannot be excl	6 N.B.	3	0	3 N.B.	1 146 678 C 539 615
oxymetazoline	cannot be excl	5 N.B.	3 N.B.	0	2 N.B.	114 226
mometasone	cannot be excl	9 N.B.	3	3	3 N.B.	7 919 135 E 6 014 275
levocabastine	insigni- ficant	4	3	0	1	53 688
budesonide	insigni- ficant	8	3	3	2	9 181 927 C 6 805 080
sodium cromoglycate	cannot be excl	3 N.B.	3 N.B.	0	0 N.B.	123 026
triamcinolone	cannot be excl	4 N.B.	3	0	1 N.B.	181 568 E 2 709 040
fluticasone	cannot be excl	6 N.B.	3	0	3 N.B.	1 768 857 C, E 3 372 380
xylometazoline	cannot be excl	7 N.B.	3	3	1 N.B.	14 513 C 2 075
beclomethasone	cannot be excl	9 N.B.	3	3	3 N.B.	176 785 C 6 805 080
pseudoephedrine	cannot be excl	-	-	-	-	C 34 000
dexbrompheniramine	cannot be excl	-	-	-	-	C 34 000
R02 Throat preparations
gramicidin	cannot be excl	-	-	-	-	4 636
R03 Drugs for obstructive airway diseases
terbutaline	insigni- ficant	3	3	0	0	4 893 706
formoterol	insigni- ficant	4	3	0	1	1 050 874 C 6 805 080
salmeterol	insigni- ficant	5	3	0	2	469 350 C 3 091 620
ipratropium	cannot be excl	6 N.B.	3	0	3 N.B.	1 146 678 C 539 615
budesonide	insigni- ficant	8	3	3	2	9 181 927 C 6 805 080
theophylline	cannot be excl	1 N.B.	0	0	1 N.B.	228 041
salbutamol	cannot be excl	4 N.B.	3	0	1 N.B.	2 999 538 C 537 540
tiotropium bromide	cannot be excl	4 N.B.	3	0	1 N.B.	3 666 550
fluticasone	cannot be excl	6 N.B.	3	0	3 N.B.	1 768 857 C, E 3 372 380
omalizumab	exempt					17 231
montelukast	insigni- ficant	2	0	0	2	2 212 787
bambuterol	insigni- ficant	4	3	0	1	12 020
ephedrine	cannot be excl	0 N.B.	0	0	0 N.B.	63 689 C 1 089 306
sodium cromoglycate	cannot be excl	3 N.B.	3 N.B.	0	0 N.B.	123 026
beclomethasone	cannot be excl	9 N.B.	3	3	3 N.B.	176 785 C 6 805 080
ciclesonide	cannot be excl	9 N.B.	3	3	3 N.B.	-
mometasone	cannot be excl	9 N.B.	3	3	3 N.B.	7 919 135 E 6 014 275
choline theophyllinate	cannot be excl	-	-	-	-	9 680
R05 Cough and cold preparations
ethylmorphine	cannot be excl	-	-	-	-	C 3 273 760
acetylcysteine	exempt					4 659 632 C 747
quillaia	exempt					C 27 620
codeine	insigni- ficant	4	3	0	1	77 315 C 6 169 528
ambroxol	insigni- ficant	5	3	0	2	300
chlorcyclizine	insigni- ficant	5	3	0	2	C 54 110
bromhexine	insigni- ficant	6	3	0	3	108 628 C 912 680
guaifenesin	cannot be excl	-	-	0	-	484
diphenhydramine	cannot be excl	-	-	-	-	C 27 620
noscapine	cannot be excl	-	-	-	-	13 727 C 43 129
pentoxyverine	cannot be excl	-	-	-	-	-
R06 Antihistamines for systemic use
loratatine	cannot be excl	6	3	0	3	2 786 542
alimemazine	cannot be excl	-	-	-	3 N.B.	2 551 387
cetirizine	cannot be excl	-	-	0	-	3 566 852
meclozine	cannot be excl	-	-	-	-	133 850
thiethylperazine	insigni- ficant	6	3	0	3	13 585
fexofenadine	insigni- ficant	6 N.B.	3	3 N.B.	0	490 765
ebastine	insigni- ficant	8	3	3	2	927 500
desloratadine	cannot be excl	5 N.B.	3	0	2 N.B.	5 655 204
cyproheptadine	cannot be excl	9 N.B.	3	3	3 N.B.	3 410
clemastine	cannot be excl	9 N.B.	3 N.B.	3	3	869 870
acrivastine	cannot be excl	-	-	0	-	-
dexchlor- pheniramine	cannot be excl	-	-	-	-	5 699
dimenhydrinate	cannot be excl	-	-	-	-	30 007
mizolastine	cannot be excl	-	-	-	-	100