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Pharmaceuticals and Environment

Here you can find information about the environmental impact of pharmaceuticals. You can search for a substance name. The environmental risk refers to the use of a pharmaceutical. The knowledge support is based on three sources:
1. environmental information from the European Medicines Agency's (EMA's) European Public Assessment Reports (EPARs)
2. environmental information on Fass.se
3. environmental risk assessments for certain substances based on concentrations measured in the environment in Sweden and effect studies.

Based on the two first-mentioned sources, environmental information is missing for many medicinal products. The database is based on Region Stockholm's work in Sweden and may mean, for example, that information about the Wise list, the drug formulary of recommended essential medicines for the entire Stockholm healthcare region, has been included.

Information about the classification

In a document there is information about the classification of the environmental hazard and the environmental risk. The classification of the risk is usually based on theoretical calculations of the risk. For more information see Classification.

For some substances there is also a risk assessment made on the basis of concentrations measured in the environment in Sweden and efficacy studies with high quality. These assessments are presented in the documents for the substances and are made by independent ecotoxicological expertise. Continuous work is underway to provide more substance documents with this type of environmental information and also present comparisons of environmental risk between substances intended for the same indication. Based on this type of risk assessment, a table of environmentally hazardous drugs Pdf, 41 kB. was developed within the framework of Region Stockholm's environmental program 2017–2021.

News

Antimicrobial resistance best practices working group report and case studies
ICMRA
November 2022

Assessing the health burden of infections with antibiotic-resistant bacteria in the EU/EEA, 2016–2020
European Centre for Disease Prevention and Control
November 2022

Sales of veterinary antimicrobial agents in 31 European countries in 2021
European Medicines Agency
2022-11-18

Modin O, Fuad N, Abadikhah M, et al. A relationship between phages and organic carbon in wastewater treatment plant effluents. Water Research X, Volume 16, 1 August 2022, 100146.

European Commission. European Green Deal: Commission proposes rules for cleaner air and water.
2022-10-26

European Commission. Proposal for a Directive amending the Water Framework Directive, the Groundwater Directive and the Environmental Quality Standards Directive.
2022-10-26

Munthe C, Malmqvist E, Rönnerstrand B (2022) Non-prescription acquisition of antibiotics: Prevalence, motives, pathways and explanatory factors in the Swedish population. PLoS ONE 17(9): e0273117. https://doi.org/10.1371/journal.pone.0273117

Moermond CTA, de Rooy M. The Dutch chain approach on pharmaceuticals in water: stakeholders acting together to reduce the environmental impact of pharmaceuticals. Br J Clin Pharmacol. 2022 https://doi.org/10.1111/bcp.15509

John P. Sumpter, Andrew. C. Johnson, Tamsin, J. Runnalls. Pharmaceuticals in the aquatic environment: No answers yet to the major questions. Environmental Toxicology and Chemistry, https://doi.org/10.1002/etc.5421

EMA guidance supports development of new antibiotics
European Medicines Agency
2022-05-24

Recommendations for greener human medicines in the revision of the EU general pharmaceuticals legislation
Health Care Without Harm
2022-03-29

Environmental dimensions of antimicrobial resistance summary for policymakers
UN environment programme
2022-03-29

Sedvall E. Pharmaceuticals are identified in insects in River Fyris – A study with both tandem quadrupole and quadrupole-time-of-flight mass spectrometry. Environmental Advances
Volume 8, July 2022, 100194.

Wilkinson JL et al. Pharmaceutical pollution of the world’s rivers. PNAS 2022 Vol. 119 No. 8 e2113947119

Antimicrobial resistance surveillance in Europe
European Centre for disease prevention and control
World Health Organization
2022

Malnes D et al. Occurrence and mass flows of contaminants of emerging concern (CECs) in Sweden's three largest lakes and associated rivers. Chemosphere Volume 294, May 2022, 133825. https://doi.org/10.1016/j.chemosphere.2022.133825

Reducing antimicrobial resistance in food production: How healthcare professionals can help
Health Care Without Harm
2022-01-21

Antimicrobial resistance collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
Lancet, DOI:https://doi.org/10.1016/S0140-6736(21)02724-0
2022-01-19

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