Alfuzosin
Summary
This summary information comes from Fass.
Persistence. It cannot be excluded that alfuzosin is persistent, due to the lack of data. Alfuzosin has been found in the Swedish aquatic environment, see further the references.
Bioaccumulation. Alfuzosin has low potential for bioaccumulation.
Toxicity. Alfuzosin has moderate acute toxicity.
Risk. The use of alfuzosin (sales data Sweden 2018) has been considered to result in insignificant environmental risk.
Detailed information
Fass environmental information
Fass environmental information for Xatral OD (alfuzosin) from Sanofi AB (downloaded 2021-07-02).
Hazard
Persistence: "The potential for persistence of alfuzosin cannot be excluded, due to lack of data."
Bioaccumulation: "log Kow of 1.51 at pH 7.4."
Acute toxicity: There are data for 3 trophic levels, lowest for algae (Pseudokirchnerellia subcapitata) > 76 600 microg/L. Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.
Risk
PEC/PNEC is based on sales data in Sweden in year 2018. PEC/PNEC = 0.00068 which gives the risk insignificant.
Pharmaceuticals residues in the aquatic environment in Region Stockholm
Alfuzosin has been detected in treated wastewater, surface water, drinking water and fish in Region Stockholm.
References
- Fass.se för vårdpersonal.
- Provtagningar av läkemedelsrester i vatten, sediment och fisk för Region Stockholm.
- IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3. Pharmaceuticals.
- IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
Author: Health and Medical Care Administration, Region Stockholm