Ganirelix
Summary
Persistence. It cannot be excluded that ganirelix is persistent, due to the lack of data.
Bioaccumulation. Ganirelix has high potential for bioaccumulation.
Toxicity. It cannot be excluded that ganirelix is toxic, due to the lack of data.
Risk. Risk of environmental impact of ganirelix cannot be excluded, due to the lack of environmental toxicity data.
This summary information comes from Fass. It is voluntary for manufacturers to provide information on environmental impact on fass.se.
Detailed information
Fass environmental information
Fass environmental information for Orgalutran (ganirelix) from Organon Sweden (downloaded 2023-09-25).
Hazard
Persistence: No data.
Bioaccumulation: Estimated Log P = 5.4 (Computed by XLogP3 3.0 (PubChem release 2019.06.18)). Since the estimated Log P > 4, the phrase chosen is “Ganirelix has high potential for bioaccumulation”
Toxicity: No data.
Risk
Risk of environmental impact of ganirelix cannot be excluded, due to the lack of environmental toxicity data.
It is voluntary for manufacturers to provide information on environmental impact on fass.se.
Assessment report
Assessment report for Ganirelix Gedeon Richter, 19 May 2022, EMA/588110/2022.
"No Environmental Risk Assessment studies were submitted. This was justified by the applicant as the introduction of Ganirelix Gedeon Richter manufactured by Chemical Works of Gedeon Richter Plc. (Gedeon Richter Plc.) is considered unlikely to result in any significant increase in the combined sales volumes for all ganirelix containing products and the exposure of the environment to the active substance. Thus, the ERA is expected to be similar and not increased."
Author: Health and Medical Care Administration, Region Stockholm